MovDisordV3, Main, Exploration, bibRecord, 004C99

Neurofibrillary tangle parkinsonian disorders—tau pathology and tau genetics

Identifieur interne : 004C99 ( Main/Exploration ); précédent : 004C98; suivant : 004D00

Neurofibrillary tangle parkinsonian disorders—tau pathology and tau genetics

Auteurs : Huw R. Morris [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Nicholas W. Wood [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 1999-09.

RBID : ISTEX:19CA8933C21173A12E38A3510EB33BA2EA5B2C18

Descripteurs français

Pascal (Inist)
- Article synthèse, Démence Pick, Gène, Homme, Mutation, Ophtalmoplégie supranucléaire, Parkinson démence ile de Guam, Pathogénie, Progressif, Protéine tau, Structure neurofibrillaire.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Brain (metabolism), Brain (pathology), Chromosome Aberrations (genetics), Chromosome Disorders, Chromosomes, Human, Pair 17 (genetics), Dementia, Dementia (genetics), FTDP‐17, Gene, Genes (genetics), Guam Parkinson dementia, Human, Humans, Mutation, Neurofibrillary Tangles (genetics), Neurofibrillary Tangles (metabolism), Neurofibrillary tangle, Parkinsonian Disorders (genetics), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (pathology), Pathogenesis, Pathology, Pick disease, Point Mutation (genetics), Progressive, Progressive supranuclear palsy, Review, Supranuclear ophthalmoplegia, Tau, Tau protein, tau Proteins (genetics), tau Proteins (metabolism).
MESH :
- chemical , genetics : tau Proteins.
- genetics : Chromosome Aberrations, Chromosomes, Human, Pair 17, Dementia, Genes, Neurofibrillary Tangles, Parkinsonian Disorders, Point Mutation.
- metabolism : Brain, Neurofibrillary Tangles, Parkinsonian Disorders, tau Proteins.
- pathology : Brain, Parkinsonian Disorders.
- Chromosome Disorders, Humans.

Abstract

A number of related conditions, including progressive supranuclear palsy (PSP), corticobasal degeneration, Pick's disease, and the parkinsonism dementia complex of Guam, are characterized by the deposition of tau neurofibrillary tangles in the absence of amyloid pathology. These diseases share some overlap in their topography and clinical features but can be subdivided into three main groups according to the isoforms of the alternatively spliced tau gene that are deposited. The recent description of mutation in tau in frontotemporal dementia, and a common variant of tau that predisposes to PSP, and the relationship of these changes to the tau protein subgroups offers new insights into the pathogenesis of these disorders.

Url:

https://api.istex.fr/document/19CA8933C21173A12E38A3510EB33BA2EA5B2C18/fulltext/pdf

DOI: 10.1002/1531-8257(199909)14:5<731::AID-MDS1004>3.0.CO;2-J

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">A number of related conditions, including progressive supranuclear palsy (PSP), corticobasal degeneration, Pick's disease, and the parkinsonism dementia complex of Guam, are characterized by the deposition of tau neurofibrillary tangles in the absence of amyloid pathology. These diseases share some overlap in their topography and clinical features but can be subdivided into three main groups according to the isoforms of the alternatively spliced tau gene that are deposited. The recent description of mutation in tau in frontotemporal dementia, and a common variant of tau that predisposes to PSP, and the relationship of these changes to the tau protein subgroups offers new insights into the pathogenesis of these disorders.</div>
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Movement Disorders (revue)

Neurofibrillary tangle parkinsonian disorders—tau pathology and tau genetics

Neurofibrillary tangle parkinsonian disorders—tau pathology and tau genetics

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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